LECTURAS CIENTÍFICAS

  • Levels of nitric oxide metabolites in cerebrospinal fluid correlate with cognitive impairment in early stage multiple sclerosis.
    Related ArticlesLevels of nitric oxide metabolites in cerebrospinal fluid correlate with cognitive impairment in early stage multiple sclerosis. J Neurol Neurosurg Psychiatry. 2017 Apr 26;: Authors: Okada K, Kobata M, Sennari Y, Iwanaka Y, Hashimoto T, Ohnari K, Tahara M PMID: 28446603 [PubMed - as supplied by publisher] ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-28
  • Six autoantibodies associated with autoimmune encephalitis are not detectable in the cerebrospinal fluid of suicide attempters.
    Six autoantibodies associated with autoimmune encephalitis are not detectable in the cerebrospinal fluid of suicide attempters. PLoS One. 2017;12(4):e0176358 Authors: Fernström J, Westrin Å, Grudet C, Träskman-Bendz L, Brundin L, Lindqvist D Abstract Previous findings suggest a link between neuroinflammatory processes and suicidality. Despite several lines of evidence supporting this link, including increased pro-inflammatory markers in blood-, cerebrospinal fluid (CSF)- and in post-mortem brain samples from suicidal individuals, the underlying mechanisms remain poorly understood. In this pilot study, we explored the possibility that autoimmune encephalopathies might be found among suicide attempters. We analysed the presence of six different autoantibodies (N-methyl-D-aspartate receptor, the α-amino-3-hydroxy-5-methyl-4-isoxazol-propionic acid receptor, the γ-amino-butyric acid B-receptor, the leucine-rich, glioma-inactivated 1, the contactin-associated protein-like 2, and the dipeptidyl-peptidase-like protein-6), all previously associated with psychopathology, in CSF samples from 29 unmedicated suicide attempters. Five of these subjects had high CSF/serum albumin ratio, indicative of increased blood-brain-barrier permeability. We were not able to detect any of these autoantibodies in the CSF samples. These pilot data do not support a role for autoimmune encephalopathies in suicidal behaviour, although the presence of lower levels of these autoantibodies cannot be ruled out in these patients.PMID: 28448609 [PubMed - in process] ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-28
  • Fingolimod attenuates experimental autoimmune neuritis and contributes to Schwann cell-mediated axonal protection.
    Related ArticlesFingolimod attenuates experimental autoimmune neuritis and contributes to Schwann cell-mediated axonal protection. J Neuroinflammation. 2017 Apr 26;14(1):92 Authors: Ambrosius B, Pitarokoili K, Schrewe L, Pedreiturria X, Motte J, Gold R Abstract BACKGROUND: Fingolimod, a sphingosine-1-phosphate receptor modulator with well-described immunomodulatory properties involving peripheral immune cell trafficking, was the first oral agent approved for the treatment of relapsing remitting multiple sclerosis. Analogous immunomodulatory treatment options for chronic peripheral autoimmune neuropathies are lacking. METHODS: We tested fingolimod in the animal model of experimental autoimmune neuritis in Lewis rat. Six to eight-week-old female rats were immunized with P2 peptide and from this day on treated with fingolimod. Histology of the sciatic nerve was done to analyze T cell and macrophage cell count, intercellular adhesion molecule (ICAM) and amyloid precursor protein (APP) expression, as well as apoptotic Schwann cell counts. RESULTS: Preventive oral treatment with 0.1 mg/kg up to 3 mg/kg fingolimod once daily dissolved in rapeseed oil completely ameliorated clinical neuritis signs. It reduced circulating peripheral blood T cells and infiltrating T cells and macrophages in the sciatic nerve, whereas at the same time, it preserved blood-nerve barrier impermeability. Most importantly, fingolimod showed beneficial properties on the pathogenic process as indicated by fewer apoptotic Schwann cells and a lower amount of amyloid precursor protein indicative of axonal damage at the peak of disease course. CONCLUSIONS: Taken together, orally administered low-dose fingolimod showed an impressive immunomodulatory effect in the rat model of experimental autoimmune neuritis. Our current observations introduce fingolimod as an attractive treatment option… ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-28
  • The Role of Peripheral Myelin Protein 2 in Remyelination.
    Related ArticlesThe Role of Peripheral Myelin Protein 2 in Remyelination. Cell Mol Neurobiol. 2017 Apr 26;: Authors: Stettner M, Zenker J, Klingler F, Szepanowski F, Hartung HP, Mausberg AK, Kleinschnitz C, Chrast R, Kieseier BC Abstract The protein component of the myelin layer is essential for all aspects of peripheral nerves, and its deficiency can lead to structural and functional impairment. The presence of peripheral myelin protein 2 (P2, PMP2, FABP8, M-FABP) in Schwann cells has been known for decades and shown recently to be involved in the lipid homeostasis in the peripheral neural system. However, its precise role during de- and remyelination has yet to be elucidated. To this end, we assessed remyelination after sciatic nerve crush injury in vivo, and in an experimental de/remyelination ex vivo myelinating culture model in P2-deficient (P2 (-/-) ) and wild-type (WT) animals. In vivo, the nerve crush paradigm revealed temporal structural and functional changes in P2 (-/-) mice as compared to WT animals. Concomitantly, P2 (-/-) DRG cultures demonstrated the presence of shorter internodes and enlarged nodes after ex vivo de/remyelination. Together, these data indicate that P2 may play a role in remyelination of the injured peripheral nervous system, presumably by affecting the nodal and internodal configuration.PMID: 28447247 [PubMed - as supplied by publisher] ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-28
  • Differences in peripheral myelin antigen-specific T cell responses and T memory subsets in atypical versus typical CIDP.
    Related ArticlesDifferences in peripheral myelin antigen-specific T cell responses and T memory subsets in atypical versus typical CIDP. BMC Neurol. 2017 Apr 26;17(1):81 Authors: Staudt M, Diederich JM, Meisel C, Meisel A, Klehmet J Abstract BACKGROUND: Chronic inflammatory demyelinating polyneuropathy (CIDP) is presented by a large heterogeneity of clinical phenotypes. Around 50% of patients suffer from typical CIDP and show better therapy response than atypical variants. The goal of our study was to search for cellular immunological differences in typical versus atypical CIDP in comparison to controls. METHODS: We evaluated 26 (9 typical, 17 atypical) patients with mainly active-unstable CIDP using clinical and immunological examinations (enzyme-linked immunospot assay ELISPOT, fluorescence-activated cell sorting FACS) in comparison to 28 healthy, age-matched controls (HC). Typical or atypical CIDP measurements were compared with HC using Kruskal-Wallis test. RESULTS: Atypical CIDP patients showed increased frequencies of T cell subsets, especially CD4+ effector memory T cells (TEM) and CD4+ central memory T cells (TCM) as well as a tendency of higher T cell responses against the peripheral myelin antigens of PMP-22, P2, P0 and MBP peptides compared to typical CIDP. Searching for novel auto-antigens, we found that T cell responses against P0 180-199 as well as MBP 82-100 were significantly elevated in atypical CIDP patients vs. HC. CONCLUSIONS: Our results indicate differences in underlying T cell responses between atypical and typical CIDP characterized by a higher peripheral myelin antigen-specific T cell responses as well as a specific altered CD4+ memory compartment in atypical CIDP. Larger multi-center… ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-28
  • Low serum levels of uric acid and albumin in patients with Guillain-Barre syndrome.
    Related ArticlesLow serum levels of uric acid and albumin in patients with Guillain-Barre syndrome. Medicine (Baltimore). 2017 Apr;96(15):e6618 Authors: Su Z, Chen Z, Xiang Y, Wang B, Huang Y, Yang D, Li X, Weng Y, Lin X, Chen G, Liu W, Zhao C, Wang Q, Li S, Chen Y, Chen Y, Quan W, Tong Q, Wu S, Huang S, Mei P, Li Z, Li J, Hou S, Zhang X Abstract Free radical toxicity due to poorly maintained cellular redox levels is crucial events that have been associated with the pathogenesis of Guillain-Barre syndrome (GBS) patients. Uric acid (UA) and albumin correlate with oxidative stress in some degree. We aimed to evaluate the relationship between GBS and serum levels of UA and albumin in the present study.The serum levels of UA and albumin were determined in 203 individuals including 88 patients with GBS and 153 healthy controls (HC).We found that serum levels of UA and albumin in patients with GBS were significantly lower than those in HC group. Besides, similar phenomenon was observed when the male and female subgroups were estimated, respectively. Additionally, we found that there is no statistic difference among subgroups of GBS regarding UA and albumin. The univariate analysis revealed that both the high UA and high albumin were protective factors for patients with GBS (odds ratio [OR] 0.140; 95% confidence interval [CI]: 0.074-0.264; P < .001 and OR 0.016; 95% CI: 0.006-0.038; P < .001, respectively). It was further confirmed by the multivariable logistic regression analysis after adjusting for other… ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-28
  • IgG4-related membranous glomerulonephritis and generalized lymphadenopathy without pancreatitis: a case report.
    Related ArticlesIgG4-related membranous glomerulonephritis and generalized lymphadenopathy without pancreatitis: a case report. BMC Nephrol. 2017 Apr 26;18(1):139 Authors: Huart J, Grosch S, Bovy C, Moutschen M, Krzesinski JM Abstract BACKGROUND: IgG4-related disease is a recently described pathologic entity. This is the case of a patient with nephrotic syndrome and lymphadenopathy due to IgG4-related disease. Such a kidney involvement is quite peculiar and has only been described a few times recently. Renal biopsy showed a glomerular involvement with membranous glomerulonephritis in association with a tubulo-interstitial nephropathy. Moreover, the patient was not suffering from pancreatitis. CASE PRESENTATION: The patient is a middle-aged man of Moroccan origin. He has developed recurrent episodes of diffuse lymphadenopathies, renal failure and nephrotic syndrome. Renal biopsies showed membranous glomerulonephritis. DISCUSSION AND CONCLUSION: The diagnostic approach of this atypical presentation is discussed in this case report as well as diagnostic criteria, therapeutic strategies, biomarkers and pathophysiology of IgG4-related disease. IgG4-related membranous glomerulonephritis is a well-established cause of membranous glomerulonephritis. It must be sought after in every patient with a previous diagnosis of IgG4-related disease and in every patient with this histological finding on renal biopsy. Corticoids are still the first-line treatment of IgG4-related disease. New therapeutic strategies are needed to avoid glucocorticoids long term side-effects. Interestingly, the patient was prescribed cyclophosphamide in addition to glucocorticoids for an immune thrombocytopenia. This treatment had a very good impact on his IgG4-related disease.PMID: 28446143 [PubMed - in process] ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-28
  • Immunostaining of Immunoglobulin G4 in the Lacrimal Sac.
    Immunostaining of Immunoglobulin G4 in the Lacrimal Sac. Ocul Immunol Inflamm. 2017 Apr 27;:1-6 Authors: Takahashi Y, Ikeda H, Takahashi E, Kakizaki H Abstract PURPOSE: To immunohistochemically examine the lacrimal sac walls harvested during dacryocystorhinostomy using an immunostain for immunoglobulin G4 (IgG4). METHODS: Forty-four lacrimal sac walls were evaluated. We determined "intensively positive," "sparsely positive," or "negative" staining when the specimens showed IgG4-positive lymphoplasmacytic staining with or without >50 IgG4-positive cells/high-power field, or the absence of stained IgG4-positive cells. RESULTS: Intensively positive, sparsely positive, or negative staining was observed in 8 (18.2%), 14 (31.8%), and 22 specimens (50.0%), respectively. Stained cells infiltrated the subepithelial layer in all specimens with positive staining. Four of the 8 specimens demonstrated partial epithelial denudation with loss of goblet cells. CONCLUSIONS: IgG4-positive lymphoplasmacytic infiltration was observed in the subepithelial layer in specimens with intensively positive staining, of which some showed a partially denuded epithelium with loss of goblet cells. These may lead to narrowing of the lacrimal sac lumen and adhesions of the sac walls.PMID: 28448722 [PubMed - as supplied by publisher] ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-28
  • Donor-Specific Antibodies in Kidney Transplant Recipients.
    Related ArticlesDonor-Specific Antibodies in Kidney Transplant Recipients. Clin J Am Soc Nephrol. 2017 Apr 26;: Authors: Zhang R Abstract Donor-specific antibodies have become an established biomarker predicting antibody-mediated rejection. Antibody-mediated rejection is the leading cause of graft loss after kidney transplant. There are several phenotypes of antibody-mediated rejection along post-transplant course that are determined by the timing and extent of humoral response and the various characteristics of donor-specific antibodies, such as antigen classes, specificity, antibody strength, IgG subclasses, and complement binding capacity. Preformed donor-specific antibodies in sensitized patients can trigger hyperacute rejection, accelerated acute rejection, and early acute antibody-mediated rejection. De novo donor-specific antibodies are associated with late acute antibody-mediated rejection, chronic antibody-mediated rejection, and transplant glomerulopathy. The pathogeneses of antibody-mediated rejection include not only complement-dependent cytotoxicity, but also complement-independent pathways of antibody-mediated cellular cytotoxicity and direct endothelial activation and proliferation. The novel assay for complement binding capacity has improved our ability to predict antibody-mediated rejection phenotypes. C1q binding donor-specific antibodies are closely associated with acute antibody-mediated rejection, more severe graft injuries, and early graft failure, whereas C1q nonbinding donor-specific antibodies correlate with subclinical or chronic antibody-mediated rejection and late graft loss. IgG subclasses have various abilities to activate complement and recruit effector cells through the Fc receptor. Complement binding IgG3 donor-specific antibodies are frequently associated with acute antibody-mediated rejection and severe graft injury, whereas noncomplement binding IgG4 donor-specific antibodies are more correlated with subclinical or chronic antibody-mediated rejection and transplant glomerulopathy. Our in-depth knowledge of complex characteristics of donor-specific… ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-28
  • Fatigue and physical functioning in children with multiple sclerosis and acute disseminated encephalomyelitis.
    Related ArticlesFatigue and physical functioning in children with multiple sclerosis and acute disseminated encephalomyelitis. Mult Scler. 2017 Apr 01;:1352458517706038 Authors: Toussaint-Duyster LC, Wong YYM, Van der Cammen-van Zijp MH, Van Pelt-Gravesteijn D, Catsman-Berrevoets CE, Hintzen RQ, Neuteboom RF Abstract BACKGROUND AND OBJECTIVE: Fatigue and physical impairments are a major concern in children with multiple sclerosis (MS) and after acute disseminated encephalomyelitis (post-ADEM). We here aimed to evaluate the interaction between fatigue, exercise capacity, motor performance, neurological status, and quality of life (HRQoL). METHODS: In this cross-sectional study, data of 38 children (MS n = 22, post-ADEM n = 16), aged 4-17 years attending our national pediatric MS center, were studied. Fatigue was measured with the Pediatric Quality of Life Multidimensional Fatigue Scale, exercise capacity with the Bruce Protocol, motor performance with the Movement Assessment Battery for Children second edition, HRQoL with the Pediatric Quality of Life Questionnaire, and extent of disability with the Expanded Disability Status Scale (EDSS). RESULTS: Children with MS and post-ADEM experienced more fatigue ( p < 0.001), reduced exercise capacity ( p < 0.001), and impaired motor performance ( p < 0.001), despite low scores on the EDSS. Fatigue, but not the other parameters, was significantly correlated with HRQoL. Fatigue was not correlated with exercise capacity. CONCLUSION: We confirm the major impact of fatigue on quality of life in children with MS and post-ADEM. Fatigue was not explained by reduced exercise capacity or impaired motor performance. An important finding for clinical practice is that the low… ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-27
  • Brain atrophy 15 years after CIS: Baseline and follow-up clinico-radiological correlations.
    Related ArticlesBrain atrophy 15 years after CIS: Baseline and follow-up clinico-radiological correlations. Mult Scler. 2017 Apr 01;:1352458517707070 Authors: Vidal-Jordana A, Sastre-Garriga J, Pareto D, Tur C, Arrambide G, Otero-Romero S, Huerga E, Mitjana R, Auger C, Tintoré M, Rovira A, Montalban X Abstract BACKGROUND: Brain atrophy in multiple sclerosis (MS) patients is present since the very early stages of the disease and it has been related to long-term disability. OBJECTIVE: To estimate brain volume (BV) at 15 years after a clinically isolated syndrome (CIS) and to evaluate its relationship with disease outcomes. METHODS: From a prospective cohort including patients presenting with a CIS, 54 patients with a brain magnetic resonance imaging (MRI) performed 15 years after CIS were included. Brain parenchymal fraction (BPF), grey matter fraction (GMF) and white matter fraction (WMF) at 15-year follow-up were obtained. Regression analyses were conducted to predict BV loss and reaching an Expanded Disability Status Scale (EDSS) of 3.0 in that 15-year period. RESULTS: In multivariable analyses, lower values of BPF and WMF were significantly associated with being male, presenting 3-4 Barkhof criteria at baseline, presenting a second relapse, and with a decision to start treatment. In the multivariable logistic regression analysis, only lower GMF was associated with a greater risk of reaching EDSS 3.0 (odds ratio (OR) = 0.24, p = 0.028). CONCLUSION: Lower BPF and WMF 15 years after CIS are associated with previous markers of inflammatory disease. Lower GMF 15 years after a CIS is associated with an increased risk of reaching an EDSS of 3.0.PMID: 28445084 [PubMed -… ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-27
  • Cerebral rituximab uptake in multiple sclerosis: A (89)Zr-immunoPET pilot study.
    Cerebral rituximab uptake in multiple sclerosis: A (89)Zr-immunoPET pilot study. Mult Scler. 2017 Apr 01;:1352458517704507 Authors: Hagens MH, Killestein J, Yaqub MM, van Dongen GA, Lammertsma AA, Barkhof F, van Berckel BN Abstract Previous studies have demonstrated that the chimeric monoclonal antibody rituximab significantly reduces clinical and radiological disease activity in relapsing-remitting multiple sclerosis as early as 4 weeks after the first administration. The exact mechanisms leading to this rapid effect have not yet been clarified. The aim of this positron emission tomography study was to assess central nervous system penetration as a possible explanation, using zirconium-89-labelled rituximab. No evidence was found for cerebral penetration of [(89)Zr]rituximab.PMID: 28443358 [PubMed - as supplied by publisher] ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-27
  • Cytokine and Chemokine Profiles in Patients with Neuromyelitis Optica Spectrum Disorder.
    Cytokine and Chemokine Profiles in Patients with Neuromyelitis Optica Spectrum Disorder. Neuroimmunomodulation. 2017 Apr 27;23(5-6): Authors: Wang Y, Zhou Y, Sun X, Lu T, Wei L, Fang L, Chen C, Huang Q, Hu X, Lu Z, Peng L, Qiu W Abstract OBJECTIVE: To screen cytokines and chemokines and determine their dynamic changes in the serum and cerebrospinal fluid (CSF) of patients with neuromyelitis optica spectrum disorder (NMOSD). METHODS: Eight NMOSD with seropositive aquaporin-4 antibody (AQP4-IgG) were enrolled, as well as 8 matched patients with multiple sclerosis (MS) and 8 with noninflammatory neurological diseases, who were included as controls. In total, 102 cytokines and 34 chemokines were detected in the CSF and serum of NMOSD patients and controls. RESULTS: CSF interleukin (IL)-17A levels were significantly higher in NMOSD patients in the relapsing phase (27.15 ± 11.33) than in those in the remitting phase (10.04 ± 3.11, p = 0.0017), and patients with MS (14.72 ± 3.20, p = 0.0283) and other controls (10.39 ± 11.38, p = 0.0021). CSF IL-6 levels were higher in the NMOSD patients in the relapsing phase (12.23 ± 3.47) than in those in the remitting phase (5.87 ± 2.78, p = 0.0001), and MS patients (7.38 ± 2.35, p = 0.0033) and other controls (7.50 ± 0.37, p = 0.0043). CSF CCL19 levels were also significantly higher in NMOSD patients in the relapsing phase (35.87 ± 27.07) than in those in the remitting phase (10.71 ± 3.62, p = 0.0215). Serum IL-19 levels were lower in… ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-27
  • Overexpression of the Cytokine BAFF and Autoimmunity Risk.
    Overexpression of the Cytokine BAFF and Autoimmunity Risk. N Engl J Med. 2017 Apr 27;376(17):1615-1626 Authors: Steri M, Orrù V, Idda ML, Pitzalis M, Pala M, Zara I, Sidore C, Faà V, Floris M, Deiana M, Asunis I, Porcu E, Mulas A, Piras MG, Lobina M, Lai S, Marongiu M, Serra V, Marongiu M, Sole G, Busonero F, Maschio A, Cusano R, Cuccuru G, Deidda F, Poddie F, Farina G, Dei M, Virdis F, Olla S, Satta MA, Pani M, Delitala A, Cocco E, Frau J, Coghe G, Lorefice L, Fenu G, Ferrigno P, Ban M, Barizzone N, Leone M, Guerini FR, Piga M, Firinu D, Kockum I, Lima Bomfim I, Olsson T, Alfredsson L, Suarez A, Carreira PE, Castillo-Palma MJ, Marcus JH, Congia M, Angius A, Melis M, Gonzalez A, Alarcón Riquelme ME, da Silva BM, Marchini M, Danieli MG, Del Giacco S, Mathieu A, Pani A, Montgomery SB, Rosati G, Hillert J, Sawcer S, D'Alfonso S, Todd JA, Novembre J, Abecasis GR, Whalen MB, Marrosu MG, Meloni A, Sanna S, Gorospe M, Schlessinger D, Fiorillo E, Zoledziewska M, Cucca F Abstract Background Genomewide association studies of autoimmune diseases have mapped hundreds of susceptibility regions in the genome. However, only for a few association signals has the causal gene been identified, and for even fewer have the causal variant and underlying mechanism been defined. Coincident associations of DNA variants affecting both the risk of autoimmune disease and quantitative immune variables provide an informative route to explore disease mechanisms and… ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-27
  • Modulation of the inwardly rectifying potassium channel Kir4.1 by the pro-invasive miR-5096 in glioblastoma cells.
    Modulation of the inwardly rectifying potassium channel Kir4.1 by the pro-invasive miR-5096 in glioblastoma cells. Oncotarget. 2017 Apr 07;: Authors: Thuringer D, Chanteloup G, Boucher J, Pernet N, Boudesco C, Jego G, Chatelier A, Bois P, Gobbo J, Cronier L, Solary E, Garrido C Abstract Inwardly rectifying potassium channels (Kir), and especially the barium-sensitive Kir4.1 encoded by KCNJ10, are key regulators of glial functions. A lower expression or mislocation of Kir4.1 is detected in human brain tumors. MicroRNAs participate in the regulation of ionic channels and associated neurologic disorders. Here, we analyze effects of miR-5096 on the Kir4.1 expression and function in two glioblastoma cell lines, U87 and U251. Using whole-cell patch-clamp and western-blot analysis, we show that cell loading with miR-5096 decreases the Kir4.1 protein level and associated K+ current. Cell treatment with barium, a Kir4.1 blocker, or cell loading of miR-5096 both increase the outgrowth of filopodia in glioma cells, as observed by time-lapse microscopy. Knocking-down Kir4.1 expression by siRNA transfection similarly increased both filopodia formation and invasiveness of glioma cells as observed in Boyden chamber assay. MiR-5096 also promotes the release of extracellular vesicles by which it increases its own transfer to surrounding cells, in a Kir4.1-dependent manner in U251 but not in U87. Altogether, our results validate Kir4.1 as a miR-5096 target to promote invasion of glioblastoma cells. Our data highlight the complexity of microRNA effects and the role of K+ channels in cancer.PMID: 28445150 [PubMed - as supplied by publisher] ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-27
  • Autoimmunity in Guillain-Barré syndrome associated with Zika virus infection and beyond.
    Related ArticlesAutoimmunity in Guillain-Barré syndrome associated with Zika virus infection and beyond. Autoimmun Rev. 2017 Apr;16(4):327-334 Authors: Pinto-Díaz CA, Rodríguez Y, Monsalve DM, Acosta-Ampudia Y, Molano-González N, Anaya JM, Ramírez-Santana C Abstract Autoimmune diseases share common immunopathogenic mechanisms (i.e., the autoimmune tautology), which explain the clinical similarities among them as well as their familial clustering. Guillain-Barré syndrome (GBS), an autoimmune peripheral neuropathy, has been recently associated with Zika virus (ZIKV) infection. Based on a series of cases, this review article provides a comparative analysis of GBS associated with ZIKV infection, contrasted with the general characteristics of GBS in light of the autoimmune tautology, including gender differences in prevalence, subphenotypes, polyautoimmunity, familial autoimmunity, age at onset, pathophysiology, ecology, genetics, ancestry, and treatment.PMID: 28216074 [PubMed - indexed for MEDLINE] ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-27
  • Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere.
    Related ArticlesZika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere. J Virol. 2016 May 15;90(10):4864-75 Authors: Lazear HM, Diamond MS Abstract Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of outbreaks accompanied by unexpectedly severe clinical complications brought this virus into the spotlight as causing an infection of global public health concern. In this review, we discuss the history and epidemiology of ZIKV infection, recent outbreaks in Oceania and the emergence of ZIKV in the Western Hemisphere, newly ascribed complications of ZIKV infection, including Guillain-Barré syndrome and microcephaly, potential interactions between ZIKV and dengue virus, and the prospects for the development of antiviral agents and vaccines. PMID: 26962217 [PubMed - indexed for MEDLINE] ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-27
  • A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report.
    Related ArticlesA case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report. Respir Med Case Rep. 2017;21:89-92 Authors: Mikumo H, Hamada N, Harada E, Yanagihara T, Ogata S, Yabuuchi H, Ijichi K, Takayama K, Nakanishi Y Abstract A 48-year-old man was admitted for evaluation of abnormal shadows on chest radiograph. Chest computed tomography (CT) showed cysts, nodules, and cervical and axillary lymphadenopathies. Elevated serum levels of IgG4 and interleukin (IL)-6 suggested IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD). Histologic findings of the cervical lymph node and right lung S(6) biopsies revealed numerous IgG4-positive plasma cells. Although CT findings of the lungs were atypical for IgG4-RD, consistent histologic findings, clinical symptoms, and laboratory data made us conclude IgG4-RD. Because histologic findings of IgG4-RD and MCD have similarities, differentiating between the two diseases should consider the clinical presentation.PMID: 28443233 [PubMed - in process] ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-27
  • Artificial Intelligence: Chess match of the century
    Artificial Intelligence: Chess match of the century Nature 544, 7651 (2017). doi:10.1038/544413a Author: Demis Hassabis Demis Hassabis lauds Garry Kasparov's account of battling supercomputer Deep Blue. ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-26
  • What happened at March for Science events around the world
    What happened at March for Science events around the world Nature 544, 7651 (2017). http://www.nature.com/doifinder/10.1038/nature.2017.21853 Authors: Sara Reardon, Nicky Phillips, Alison Abbott, Barbara Casassus, Ewen Callaway, Alexandra Witze, Corie Lok & Emiliano Rodriguez Mega Nature reported from marches in cities including Sydney, Washington DC and Paris, as people took to the streets in support of science. ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-26
  • Planetariums — not just for kids
    Planetariums — not just for kids Nature 544, 7651 (2017). http://www.nature.com/doifinder/10.1038/544395a Author: Tom Kwasnitschka Planetariums are not just for education, or even astronomy: they could display all sorts of data, if only scientists thought to use them, says Tom Kwasnitschka. ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-26
  • Neurosurgery: Gentler alternatives to chips in the brain
    Neurosurgery: Gentler alternatives to chips in the brain Nature 544, 7651 (2017). doi:10.1038/544416c Author: Robert Ajemian As physicians and neuroscientists, we are concerned about the clinical and scientific limitations of chip-in-the-brain technology. Until these problems are overcome, we argue that less invasive methods could be used.Implantation of an electronic chip requires opening the skull and inserting the chip into the ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-26
  • Predatory journals: Beall’s List is missed
    Predatory journals: Beall's List is missed Nature 544, 7651 (2017). doi:10.1038/544416b Author: Wadim Strielkowski Beall's List of predatory publishers, now withdrawn, was instrumental in the fight against the dubious practices of some online open-access science journals (see P.Sorokowskiet al. Nature543, 481–483; 2017). To borrow a metaphor from James Woolsey, director ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-26
  • Surprise El Niño causes devastation but offers lessons for ecologists
    Surprise El Niño causes devastation but offers lessons for ecologists Nature 544, 7651 (2017). http://www.nature.com/doifinder/10.1038/544405a Author: Barbara Fraser How Peruvian coastal deserts respond to rains will aid future disaster response. ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-26
  • March for Science, climate engineering and China’s space station
    March for Science, climate engineering and China's space station Nature 544, 7651 (2017). http://www.nature.com/doifinder/10.1038/544398a The week in science: 21–27 April 2017 ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-26
  • Environment: An old clue to the secret of longevity
    Environment: An old clue to the secret of longevity Nature 544, 7651 (2017). doi:10.1038/544416e Authors: Panagiota Pietri, Theodore Papaioannou & Christodoulos Stefanadis Epidemiologists are seeking to identify the lifestyle and environmental factors that make the Greek inhabitants of Ikaria, a small island in the Aegean Sea, one of the world's longest-lived populations (see go.nature.com/2nzec7y and P.Pietriet al. J. Am. Coll. Cardiol.66, ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-26
  • Liquid-biopsies success highlights power of combining basic and clinical research
    Liquid-biopsies success highlights power of combining basic and clinical research Nature 544, 7651 (2017). doi:10.1038/544393a Using free-floating DNA to detect lung cancer brings benefits to researchers and patients alike. ... leer mas
    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-26
  • California’s $3-billion bet on stem cells faces final test
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    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-26
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    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-26
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    Fuente: CIENCIA – INOREADERPublicado en: 2017-04-26